2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Property

Density 

1.480±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMSO: soluble20mg/mL, clear

pka

10.87±0.70(Predicted)

form 

powder

color 

white to beige

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/38

Safety Statements 

26

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-(N-(5-chloro-2-Methylphenyl)MethylsulfonaMido)-N-(2,6-difluorophenyl)acetaMide Chemical Properties,Usage,Production

Uses

2-(N-(5-Chloro-2-methylphenyl)methylsulfonamido)-N-(2,6-difluorophenyl)acetamide is a small molecule that enhances hepatocyte functions and promotes the differentiation if induced pluripotent stem cell-derived hepatocytes towards a more mature phenotype than what was previously obtainable.

Biological Activity

fph1 is a small molecule that promotes the functional proliferation of primary hepatocytes [1].fph1 belongs to the functional proliferation hits which are screened out by their ability to permit renewable sourcing of functional human hepatocytes. this ability of fph1 is not dependent on the donors of the hepatocytes. it has been found that fph1 was active against the primary human hepatocytes from six cell sources of genetically diverse individuals. besides that, fph1 can affect the hepatocyte functions with promoting albumin secretion during the differentiation of ips cells into iheps. moreover, treatment of fph1 also resulted in the increase of cyp3a4 levels and the decrease of afp secretion [1].

References

[1] shan j, schwartz r e, ross n t, et al. identification of small molecules for human hepatocyte expansion and ips differentiation. nature chemical biology, 2013.